Studying slime.

Oestrogen receptor protein (ER) was detected in 9 of 11 samples of malignant breast tissue and 8 of 9 samples of normal breast tissue. Levels of cytosolic ER (ERJ) in malignant breast were 21-1102 fmol mgsoluble protein (Kd1.8x 10-9-3.1 x 10-8moll-1) and those of nucleosolic ER (ERj), 13-526fmolmg-' soluble protein (Kd 2.1 x 10-9-1.4 x 10 8mol '1). In normal breast tissue ERC levels were 33-640fmol mgsoluble protein (Kd 1.3 x 10-L-3.2 x 0mol -'), ER. was detected in only 2 samples, 8 and 87 fmolmg' soluble protein with Kd 3.2 x 109 and 1.4 x 1091 mol -' respectively. 17a-ethinyl13,-ethyl-17,-hydroxy-4,15gonadiene-3-one (gestodene), a new synthetic progestogen displaced 3H-oestradiol (3H-E2) from both ERc and ERn in malignant tissue but not in normal breast, or these receptors from endometrial tissue. In